pigkMutation underliesmachobehavior and affects Rohon-Beard cell excitability
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چکیده
منابع مشابه
pigk Mutation underlies macho behavior and affects Rohon-Beard cell excitability.
The study of touch-evoked behavior allows investigation of both the cells and circuits that generate a response to tactile stimulation. We investigate a touch-insensitive zebrafish mutant, macho (maco), previously shown to have reduced sodium current amplitude and lack of action potential firing in sensory neurons. In the genomes of mutant but not wild-type embryos, we identify a mutation in th...
متن کاملActivity regulates programmed cell death of zebrafish Rohon-Beard neurons.
Programmed cell death is a normal aspect of neuronal development. Typically, twice as many neurons are generated than survive. In extreme cases, all neurons within a population disappear during embryogenesis or by early stages of postnatal development. Examples of transient neuronal populations include Cajal-Retzius cells of the cerebral cortex and Rohon-Beard cells of the spinal cord. The nove...
متن کاملMuscle contractions guide rohon-beard peripheral sensory axons.
Multiple molecular cues guide neuronal axons to their targets during development. Previous studies in vitro have shown that mechanical stimulation also can affect axon growth; however, whether mechanical force contributes to axon guidance in vivo is unknown. We investigated the role of muscle contractions in the guidance of zebrafish peripheral Rohon-Beard (RB) sensory axons in vivo. We analyze...
متن کاملProgrammed cell death in zebrafish rohon beard neurons is influenced by TrkC1/NT-3 signaling.
Rohon Beard (RB) cells are embryonic primary sensory neurons that are removed by programmed cell death during larval development in zebrafish. RB somatosensory functions are taken over by neurons of the dorsal root ganglia (DRG), suggesting that RB cell death may be triggered by the differentiation of these ganglia, as has been proposed to be the case in Xenopus. However, here we show that the ...
متن کاملRohon-Beard neuron origin from blastomeres of the 16-cell frog embryo.
Clonal origins of Rohon-Beard neurons in Xenopus were determined quantitatively by injecting horseradish peroxidase into individual blastomeres at the 16-cell stage and later counting labeled and unlabeled Rohon-Beard neurons. Two different patterns of cleavage were selected. In pattern X, all Rohon-Beard neurons originated from three blastomeres (V1.1, V1.2, and V2.2) on each side; in pattern ...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2015
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00355.2015